Stay Ahead of AI Threats: Secure LLM Applications with Trend Vision One

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By Fernando Cardoso, Dave McDuff, Fernando Tucci, Kim Kinahan, and David Girard

According to the World Economic Forum's Global Cybersecurity Outlook 2025, only 37% of organizations have processes in place to assess the security of AI tools before deployment. This alarming statistic highlights the significant security gap as businesses rush to implement AI technologies without adequate protection measures.

Large language models (LLMs) have become the driving force behind today’s most recognizable and widely adopted form of AI. From internet-wide AI assistants to tools embedded across industries, LLMs are changing how organizations handle data, interact with customers, and conceive further innovation.

Yet with every technological leap comes new risk. The power of LLMs inevitably introduces security challenges that can lead to unanticipated and serious consequences. That’s where the OWASP Top 10 for LLM Applications comes in, identifying and preparing industries for the most critical vulnerabilities in this developing AI landscape.

The real question now is how organizations can turn awareness of these risks into actionable solutions. Trend Micro offers answers with Trend Vision One™, an enterprise cybersecurity platform designed to address these vulnerabilities.

Key Components of Trend Vision One

Trend Vision One is a platform that provides integrated protection across AI, endpoints, networks, cloud environments, email systems, and more. It does this through the combination of key components, outlined here:

Zero Trust Secure Access

Secures all access, internal and cloud, across users, devices, location, and environments at any time, using private access, internet access, and risk control rules.

ZTSA AI Service Access

Controls and inspects traffic to and from public and private generative AI services, which helps prevent prompt injection, unauthorized use, and abuse of AI endpoints.

AI Security Posture Management (AI-SPM)

Provides visibility into AI-related cloud assets, detecting misconfigurations, unauthorized access, and potential attack paths.

AI App Guard

Protects AI applications from tampering or unauthorized changes by identifying suspicious programs attempting to modify AI applications and files.

Container Protection

Ensures that only trusted containers are deployed and keeps pipelines monitored for threats, vulnerabilities, and compliance violations.

TippingPoint™

Delivers real-time, in-line threat protection for AI infrastructure by preventing exploitation of vulnerabilities through network-based attacks.

Server & Workload - Intrusion Prevention System

These Endpoint protection rules safeguard AI servers and workloads against known and zero-day vulnerabilities through automated virtual patching.

Mapping Solutions to the OWASP Top 10 for LLM Applications (2025)

By combining these components, Trend Vision One provides a comprehensive approach that addresses seven of the ten OWASP-identified Top 10 LLM risks, with additional coverage currently in development.

Table 1. Overview of Trend Vision One solutions addressing seven of the top LLM security risks identified by OWASP in 2025

With these components in place, Trend Vision One provides a strong foundation for securing LLM applications, with advanced capabilities actively being developed to address the remaining OWASP Top 10 AI vulnerabilities:

• Data and Model Poisoning (LLM04): Our security roadmap prioritizes sophisticated detection mechanisms to identify and prevent poisoning attempts that could compromise model integrity. These protections will safeguard the entire AI lifecycle, from development to deployment, ensuring your models remain trustworthy and reliable.
• System Prompt Leakage (LLM07): To combat the risk of prompt exposure, we're developing comprehensive audit capabilities that enable regular, systematic security reviews of all prompt handling processes. These tools will help identify vulnerabilities in how prompts are stored, transmitted, and accessed, ensuring your proprietary instructions and intellectual property remain protected from unauthorized extraction or manipulation.
• Misinformation (LLM09): To combat the growing challenge of AI-generated misinformation, our roadmap includes advanced content verification tools that analyze outputs for accuracy, bias, and potential harm. These capabilities will help maintain trust in your AI systems and protect your brand reputation.

As a Gold Sponsor of the OWASP Top 10 for LLM and Gen AI project, Trend Micro demonstrates our commitment to not just following industry standards but actively shaping them. This strategic involvement ensures our customers benefit from security solutions that anticipate emerging threats before they impact your business.

From Insights to Solutions

The OWASP Top 10 for LLM Applications is an essential resource, identifying the most urgent security concerns in one of today’s most widely used forms of generative AI. However, a list by itself is not enough.

Real value comes from concrete steps to act on what OWASP outlines. With Trend Vision One, Trend Micro transforms these insights into defenses and embeds security into AI innovation.

Learn more about each vulnerability on the list and get a more detailed look at how Trend Micro’s integrated security aligns with OWASP’s guidance for LLM applications by downloading this white paper.